Based on the results obtained from the ANI technology on the monitoring of non-communicating adults patients, 3 more years of research and development were necessary to give birth to the NIPE index (Newborn Infant Parasympathetic Evaluation). The NIPE technology enables the evaluation of the parasympathetic part of the autonomic nervous system of newborns, from premature to the age of 2 years, from the electrocardiogram provided by the multi parametric monitor.